Gossypol: A Potential Contraceptive for MenSheldon J. Segal Springer Science & Business Media, 6 дек. 2012 г. - Всего страниц: 286 The search for a reversible male contraceptive has centered upon the suppression of sperm production or sperm motility. Gossypol, a natural substance extracted from the cotton plant, appears to cause both of these effects. Its ability to reduce spermatogenesis in men is undeniable and has been demonstrated in both large studies in China and a smaller confirmatory study in Brazil. These investiga tions have revealed the remarkable fact that with gossypol, it is possible to separate an effect on the testis' gamete-producing function from an effect on its hormone-producing function. Thus, it is possible to maintain normal testosterone levels and libido while sperm counts (and motility) fall. Because of this unique and important action, gossypol warrants the fullest possible evaluation as a potential male contraceptive. Sheldon J. Segal vii ACKNOWLEDGMENT Lynn C. Landman played a major role in this publication by skillfully editing the manuscripts which were submitted for inclusion in this volume. Janet O'Connell added her efforts in editing, assembling texts and figures and handling final details required for publication. I thank these talented colleagues for their invaluable contributions. |
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Trial of Gossypol as a Male Contraceptive | 9 |
Biphasic Action of Gossypol in Men | 25 |
Effect of Gossypol on the Fertility of the Male | 33 |
Assessment of Toxicity and Antifertility Efficacy | 44 |
The Arrhythomogenic Effect of Gossypol | 59 |
Gossypol Studies in Male Rats | 67 |
Embryonic and Reproductive Toxicity Evaluation | 79 |
Ultrastructural Biochemical and Endocrine | 143 |
A Solid Phase Radioimmunoassay for Gossypol | 187 |
Evaluation of Gossypols Effect on Bull | 203 |
Influence of Gossypol on the Motility and Dynein | 215 |
Binding of CGossypol by Arbacia Sperm | 227 |
Biochemical Studies of Gossypol | 237 |
Deactivation of Spermatozoal Fertilizing Capability | 245 |
Uptake of CGossypol by Murine Erythroleukemia | 257 |
A Reproduction and Teratology Study with Gossypol | 89 |
Effect of Gossypol on Prostatic Androgen | 111 |
Effect of Gossypol on Accumulation of Rhodamine123 | 119 |
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A. P. Hoffer acrosin action potentials activity adenyl cyclase Androl animals antifertility effect Arbacia assay ATPase binding Biol body weight buffer C. S. Lee Chinese concentration of gossypol decrease doses of gossypol dynein ATPase effect of gossypol electron enzyme epididymal epididymal sperm fetus fetuses gossy gossypol acetic acid gossypol inhibition gossypol treatment gossypol-treated rats Group on Male hamsters hormone inactivation incubation infertility LDH-X levels M. C. Chang Male Antifertility Agents male contraceptive male rats matings medium MELC membrane metabolism mg/kg/day of gossypol mitochondria monkeys morphology National Coordinating Group observed plasma prostate protein pups rabbits rats treated Reprod semen seminiferous Sertoli cells serum significant sperm count sperm motility spermatids spermatogenesis spermatozoa Sternebrae Table testes testicular testosterone thyroglobulin tion toxicity TR-ST cells tubes ultrastructural uptake vitro weeks of treatment weight gain