Excitatory Amino Acids: Clinical Results with AntagonistsPaul L. Herrling Elsevier, 10 янв. 1997 г. - Всего страниц: 156 Glutamate is the major excitatory neurotransmitter in the brain and dysfunction of glutamate transmission is the likely cause of a variety of diseases including neurodegeneration following cerebral ischemia, Huntington's chorea, amyotrophic lateral sclerosis, epilepsy, spasticity, emesis, chronic pain, and schizophrenia. Excitatory amino acid receptor agonists and antagonists are therefore of major interest as potential drugs for central nervous system disorders. Excitatory Amino Acids is the first book entirely dedicated to the results of human testing of modulators of excitatory amino acid neurotransmitters.
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Содержание
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Chapter 3 Intrathecal Administration of a Competitive NMDA Receptor Antagonist for Pain Treatment | 23 |
Chapter 4 Clinical Experience with the NMDA Ion Channel Blocker Aptiganel Hydrochloride CERESTAT | 31 |
Chapter 5 Development of ACPC A Partial Agonist of the Glycine Site on the NMDA Receptor | 43 |
Neuroprotective NMDA Receptor Antagonists and Calcium Channel Blockers | 57 |
A Selective and Competitive AMPAKainate Receptor Antagonist | 81 |
Chapter 8 The NBQX Story | 89 |
Chapter 9 Riluzole in Amyotrophic Lateral Sclerosis | 99 |
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Glossary | 121 |
Summary Table of Compounds and Their Clinical Status | 125 |
References | 129 |
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Excitatory Amino Acids: Clinical Results with Antagonists P. L. Herrling Недоступно для просмотра - 1997 |
Часто встречающиеся слова и выражения
30 mg kg 7-chlorokynurenate ACPC activity administration adverse events affinity agonist allodynia AMPA animal models antagonism anticonvulsant aptiganel aptiganel HCl artery assessed block bolus cerebral ischemia Chapter compound cortex cortical D-CPPene disease DL-CPP drug effects of ifenprodil efficacy excitatory amino acid excitotoxic focal ischemia function global ischemia glycine H]ifenprodil binding ICso ifenprodil ifenprodil and eliprodil increase induced infusion inhibition intrathecal intravenous kainate ketamine ligands metabolite mg day mg kg i.p. mice N-methyl-D-aspartate NBQX neurological neuronal neuroprotective neuroprotective effects neurotoxicity NMDA antagonists NMDA receptor antagonist observed occlusion onset oral pain patients Paul Vaillant-Couturier pharmacokinetics Pharmacol pharmacological phencyclidine pig kg placebo plasma concentrations polyamine potential reduced remacemide hydrochloride riluzole safety seizures selfotel side-effects significant spermidine spermine spinal cord subtypes subunit Synthélabo Synthélabo Recherche Table tion tolerance toxicity traumatic brain injury treatment unpublished data vitro vivo volunteers