Progress in Medicinal Chemistry

Abstr acid Acta action activity alkaloids alkyl Amer anaesthesia anaesthetic animals anticonvulsant antitussive appears Arch assay Biol block blood brain Brit caused cent central chem chemical clinical codeine compared compounds concentrations corresponding cough derivatives described determined dose drug effect epilepsy error esters estimates evidence example experiments given guinea-pigs important increase inhibition injection latter less levels lignocaine limits Lond mean measure method mg/kg mice Nature nerve observed obtained patients Pharm Pharmacodyn Pharmacol pharmacological Physiol possess possible potency preparation probably Proc procaine produced properties rabbit ratio rats recently reduced relatively reported reserpine response ring seizures showed shown significant similar species squares standard stimulation structure substance substituted suggested synthesized Table tissue toxicity treatment trial tubocurarine values variance various