Excitatory Amino Acids and EpilepsySpringer Science & Business Media, 6 дек. 2012 г. - Всего страниц: 735 Human epilepsy is a major public health problem affecting approximately 2 persons per 1000. It is particularly frequent in ohildren where convul sions may lead to brain damage and subsequent seizure activity in adulthood. Temporal lobe epilepsy (synonyms include limbic epilepsy. psychomotor epilepsy and complex partial epilepsy) is the most devastating form of epilepsy in the adult population since: a) it is often extremely resistant to currently available anticonvulsant drugs (i.e •• it is more resistant than tonico-clonic or grand mal seizures) and b) it includes loss of consciousness. thereby limiting performance of many normal functions and leaving the individual susceptible to bodily injury. It is also associated with nerve cell loss. in particular in the hippocampus and other structures of the temporal lobes. In order to promote an appropriate therapy it is essential to understand the etiology of seizures and its relationship to brain damage. Basic research on epilepsy also provides a very useful vehicle to learn about the way the brain functions under normal conditions. For instance. much of our present understanding of the mechanisms of action of GABA and benzo diazepines. control of neuronal activity. etc. has been derived from such stUdies. |
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Cortical and Subcortical Afferents of the Amygdaloid | 35 |
Putative Amino Acid Transmitters in the Amygdala | 53 |
A Survey of the Anatomy of the Hippocampal Formation | 67 |
Cytochemical Architecture of the Entorhinal Area | 83 |
Commentary | 99 |
Metabolic Morphologic and Electrophysiologic | 115 |
Inward Currents in Cat Neocortical Neurons | 401 |
Synchronization of Pyramidal Cell Firing | 413 |
Excitatory Amino Acids and Regenerative Activity | 425 |
LongTerm Alterations in Amino AcidInduced Ionic | 439 |
Commentary | 461 |
Effects of Kainate on CA1 Hippocampal Neurons Recorded | 475 |
The Membrane Action of Excitatory Amino Acids | 497 |
A PatchClamp Study of Excitatory Amino Acid | 507 |
Endogenous Excitotoxins as Possible Mediators | 127 |
Role of the Substantia Nigra in the Kindling Model | 139 |
Long Term Sequelae of Parenteral Administration | 147 |
Pathophysiological Aspects of BloodBrain Barrier | 175 |
BloodBrain Barrier Permeability to Excitatory | 191 |
Limbic Seizures Induced by Systemically Applied | 199 |
Ultrastructural Analysis of Rat Brain Tissue Following | 223 |
Commentary | 231 |
Excitatory Amino Acid Pathways in the Brain | 263 |
Synthesis and Release of Amino Acid Transmitters | 285 |
Commentary | 317 |
Glutamic Acid Release | 331 |
AntiExcitotoxic Actions of Taurine in the | 349 |
Alterations in Extracellular Amino Acids and Ca2+ | 363 |
Do They Act at Putative | 375 |
Commentary | 385 |
Expression of Vertebrate Amino Acid Receptors | 525 |
Commentary | 539 |
ZincBinding Proteins in the Brain | 557 |
Neurobehavioral Neuroendocrine and Neurochemical | 571 |
Excitatory Amino Acids and Divalent Cations in | 587 |
Effect of Zinc on Neuronal Activity in the | 599 |
Relationship of Glutamic Acid and Zinc to Kindling | 611 |
Commentary | 625 |
401 | 645 |
Selective and Nonselective Seizure Related Brain | 647 |
On the Role of Seizure Activity and Endogenous | 659 |
Glutamate and Anoxic Neuronal Death In Vitro | 687 |
Commentary | 709 |
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