Excitatory Amino Acids and Epilepsy

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Springer Science & Business Media, 6 дек. 2012 г. - Всего страниц: 735
Human epilepsy is a major public health problem affecting approximately 2 persons per 1000. It is particularly frequent in ohildren where convul sions may lead to brain damage and subsequent seizure activity in adulthood. Temporal lobe epilepsy (synonyms include limbic epilepsy. psychomotor epilepsy and complex partial epilepsy) is the most devastating form of epilepsy in the adult population since: a) it is often extremely resistant to currently available anticonvulsant drugs (i.e •• it is more resistant than tonico-clonic or grand mal seizures) and b) it includes loss of consciousness. thereby limiting performance of many normal functions and leaving the individual susceptible to bodily injury. It is also associated with nerve cell loss. in particular in the hippocampus and other structures of the temporal lobes. In order to promote an appropriate therapy it is essential to understand the etiology of seizures and its relationship to brain damage. Basic research on epilepsy also provides a very useful vehicle to learn about the way the brain functions under normal conditions. For instance. much of our present understanding of the mechanisms of action of GABA and benzo diazepines. control of neuronal activity. etc. has been derived from such stUdies.
 

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Amygdalohippocampal and Amygdalocortical Projections
3
Subcortical Projections from the Amygdaloid Complex
19
Cortical and Subcortical Afferents of the Amygdaloid
35
Putative Amino Acid Transmitters in the Amygdala
53
A Survey of the Anatomy of the Hippocampal Formation
67
Cytochemical Architecture of the Entorhinal Area
83
Commentary e e o e e o e o e s e e s
99
Metabolic Morphologic and Electrophysiologic
115
Inward Currents in Cat Neocortical Neurons
401
Synchronization of Pyramidal Cell Firing
413
Excitatory Amino Acids and Regenerative Activity
425
LongTerm Alterations in Amino AcidInduced Ionic
439
Excitatory Amino Acids and EpilepsyInduced Changes
449
Commentary
461
Effects of Kainate on CA1 Hippocampal Neurons Recorded
475
Blockade by DAminophosphonovalerate or Mg2+
485

Endogenous Excitotoxins as Possible Mediators
127
Role of the Substantia Nigra in the Kindling Model
139
Long Term Sequelae of Parenteral Administration
147
What
157
Pathophysiological Aspects of BloodBrain Barrier
175
BloodBrain Barrier Permeability to Excitatory
191
Limbic Seizures Induced by Systemically Applied
199
Extravasated Protein as a Cause of Limbic SeizureInduced
211
Ultrastructural Analysis of Rat Brain Tissue Following
223
Commentary
231
Excitatory Amino Acid Pathways in the Brain e
263
Synthesis and Release of Amino Acid Transmitters
285
Na Fluxes as a Tool to Identify Anticonvulsant
295
Involvement of Excitatory Amino Acid Receptors
303
Commentary
317
Glutamic Acid Release
331
AntiExcitotoxic Actions of Taurine in the
349
Alterations in Extracellular Amino Acids and Ca2+
363
Do They Act at Putative
375
Commentary e
385
The Membrane Action of Excitatory Amino Acids
497
A PatchClamp Study of Excitatory Amino Acid
507
Expression of Vertebrate Amino Acid Receptors
525
Commentary
539
ZincBinding Proteins in the Brain e e s e e
557
Neurobehavioral Neuroendocrine and Neurochemical
571
Excitatory Amino Acids and Divalent Cations in
587
Effect of Zinc on Neuronal Activity in the
599
Relationship of Glutamic Acid and Zinc to Kindling
611
Commentary e s e s e e e s
625
Selective and Nonselective Seizure Related Brain
647
On the Role of Seizure Activity and Endogenous
659
Insights
673
Glutamate and Anoxic Neuronal Death In Vitro
687
A Pathogen in Seizure Disorders?
697
Commentary
709
Index
729
321
732
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