Xeno: The Promise of Transplanting Animal Organs into Humans

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Oxford University Press, 23 мар. 2000 г. - Всего страниц: 304
The plight of a patient waiting months, sometimes years, for an organ transplant is one of the most heart-wrenching predicaments confronting medicine today. But the current critical shortage of human donor organs has had one positive consequence: it has stimulated promising new research into the field of xenotransplantation--the transplantation of organs from one animal species to another. In Xeno: The Promise of Transplanting Animal Organs Into Humans, David Cooper and Robert Lanza explore what may become one of the greatest medical advances of the 21st century. As scientists genetically engineer animal organs to evade the problems of rejection, we can expect a tremendous increase in xenotransplantation. This book recounts the several historical attempts to transplant animal organs into humans, and draws attention to the immense potential and promise of this form of therapy. The problems which remain, and recent breakthroughs in overcoming rejection and in "humanizing" pig organs for transplantation, are fully discussed. The authors also provide a fascinating consideration of the social and ethical questions posed by such procedures. Which patients should be the first to be offered this new form of therapy? Will transplanted animal organs transfer infectious viruses to the human recipient, and will they then be passed on to the community at large? Can society afford the major increase in healthcare expenditure that will result from our ability to provide a limitless number of donor organs? With profound implications for human health and longevity in the next millennium, Xeno is essential reading for anyone interested in the future of medicine.
 

Содержание

Organ transplantation today and tomorrow
1
Supply and demand in the world of organ transplantation
6
Mans early attempts to bridge the species gap
24
The choice of donor
44
The rejection of animal organs
55
Preventing rejection
70
Manipulating the genes of the donor
90
Tolerance
107
The selection of the first patients
176
Ethical concerns
190
Government regulations and safeguards
210
Potential legal problems
221
Animal transplants and health care economics
230
17 A Vision with a Task
248
Appendix
251
Glossary of selected biomedical terms
253

Cells that will make a difference
120
Will the transplanted organ work?
147
The fear of an AIDSlike epidemic
160

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Стр. vii - The creatures outside looked from pig to man, and from man to pig, and from pig to man again; but already it was impossible to say which was which.

Об авторе (2000)

David Cooper, MD, is an Immunologist at the Transplantation Biology Research Center, Massachusetts General Hospital, and an Associate Professor of Surgery at Harvard Medical School. Robert Lanza, MD, is Senior Director of Tissue Engineering and Transplant Medicine, Advanced Cell Technology, Inc.

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