Xeno: The Promise of Transplanting Animal Organs into HumansOxford University Press, 23 мар. 2000 г. - Всего страниц: 304 The plight of a patient waiting months, sometimes years, for an organ transplant is one of the most heart-wrenching predicaments confronting medicine today. But the current critical shortage of human donor organs has had one positive consequence: it has stimulated promising new research into the field of xenotransplantation--the transplantation of organs from one animal species to another. In Xeno: The Promise of Transplanting Animal Organs Into Humans, David Cooper and Robert Lanza explore what may become one of the greatest medical advances of the 21st century. As scientists genetically engineer animal organs to evade the problems of rejection, we can expect a tremendous increase in xenotransplantation. This book recounts the several historical attempts to transplant animal organs into humans, and draws attention to the immense potential and promise of this form of therapy. The problems which remain, and recent breakthroughs in overcoming rejection and in "humanizing" pig organs for transplantation, are fully discussed. The authors also provide a fascinating consideration of the social and ethical questions posed by such procedures. Which patients should be the first to be offered this new form of therapy? Will transplanted animal organs transfer infectious viruses to the human recipient, and will they then be passed on to the community at large? Can society afford the major increase in healthcare expenditure that will result from our ability to provide a limitless number of donor organs? With profound implications for human health and longevity in the next millennium, Xeno is essential reading for anyone interested in the future of medicine. |
Содержание
Organ transplantation today and tomorrow | 1 |
Supply and demand in the world of organ transplantation | 6 |
Mans early attempts to bridge the species gap | 24 |
The choice of donor | 44 |
The rejection of animal organs | 55 |
Preventing rejection | 70 |
Manipulating the genes of the donor | 90 |
Tolerance | 107 |
The selection of the first patients | 176 |
Ethical concerns | 190 |
Government regulations and safeguards | 210 |
Potential legal problems | 221 |
Animal transplants and health care economics | 230 |
17 A Vision with a Task | 248 |
Appendix | 251 |
Glossary of selected biomedical terms | 253 |
Cells that will make a difference | 120 |
Will the transplanted organ work? | 147 |
The fear of an AIDSlike epidemic | 160 |
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Часто встречающиеся слова и выражения
allograft animal organ anti-Gal anti-pig antibodies antigens baboon blood cells blood vessels body body’s brain cause chimpanzee chronic rejection clinical trial cloning complement cost develop device diabetes dialysis donor organ enzyme erythropoietin ethical example factors function gene genetic engineering graft heart transplant hepatitis hormone hospital human donor human organ human patients human recipient hyperacute rejection immune response immune system immunological immunosuppressive drug immunosuppressive drug therapy implanted infection insulin islet cells kidney transplant large numbers liver failure liver transplant lung microorganisms molecules monkeys nonhuman primate º º º organ donation organ transplantation pancreas performed perfusion pig cells pig heart pig kidney pig liver plantation plasma potential prevent problems procedure produce proteins prove recipient’s risk species successful sugar surgical survival tion tissue type tolerance trans transferred transgenic transplant center transplant surgeon transplanted human organ transplanted organ virus viruses xeno xenograft xenotrans xenotransplant xenotransplantation
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Стр. vii - The creatures outside looked from pig to man, and from man to pig, and from pig to man again; but already it was impossible to say which was which.