Stress, the aging brain, and the mechanisms of neuron death
Looking beyond the now widely recognized relationships between stress and physical illness, this accessible and engagingly written book suggests that stress and stress-related hormones can also endanger the brain
xi, 427 pages : illustrations ; 26 cm
9780262193207, 0262193205
25048058
pt. I. The Glucocorticoid Cascade Hypothesis. 1. The Stress-Response and the Emergence of Stress-Related Disease. 2. An Introduction to the Adrenocortical Axis. 3. Glucocorticoid Concentrations in the Aged Rat: A Problem of Hypersecretion. 4. The Problem of Receptor Loss. 5. The Hippocampus as a Mediator of Glucocorticoid Feedback Regulation. 6. Glucocorticoid Neurotoxicity
pt. II. How Does a Neuron Die? 7. Glucocorticoids Endanger Hippocampal Neurons. 8. A Brief Interlude: Programmed Cell Death. 9. Metabolic Chaos I: The Mediators of Necrotic Neuronal Injury. 10. Metabolic Chaos Il: The Role of Energy Failure in Necrotic Neuronal Injury. 11. How Do Glucocorticoids Endanger the Hippocampal Neuron?
pt. III. How Depressing Is All of This? 12. Individual Differences and Adrenocortical Function: Why Do Some Individuals Secrete More Glucocorticoids Than Others? 13. Interventions at the Time of Neurological Insults. 14. Is This Relevant to the Human?
"A Bradford book."