Immunotoxicology of drugs and chemicals : an experimental and clinical approach

Cover

Preface

Contents

Chapter 1 Definition, history, and scope of immunotoxicology

Definition of immunotoxicology

A short history of immunotoxicology

The scope of immunotoxicology

References

Chapter 2 The immune system: a toxicologist's overview

Introduction

The lymphoid organs

Immunocompetent cells

Innate (natural) immunity

Adaptive (specific) immunity

External influences on the immune system

Conclusion

References

Chapter 3 Health consequences of immunotoxic effects

Introduction

Immunosuppression

Immunostimulation

Hypersensitivity

Autoimmunity

Conclusion

References

Chapter 4 Mechanisms of immunotoxic effects

Introduction

Mechanisms of immunosuppression

Mechanisms of immunostimulation

Mechanisms of hypersensitivity reactions

Structure-immunotoxicity relationships

Conclusion

References

Chapter 5 Nonclinical evaluation of unexpected immunosuppression

Introduction

Histopathology

Hematology and clinical chemistry

Measurement of humoral immunity

Measurement of cellular immunity

Measurement of innate immunity

Host resistance models

Conclusion

References

Chapter 6 Nonclinical evaluation of unexpected immunostimulation

Introduction

Histopathology

Hematology and clinical chemistry

Immune function assays

Cytokine release assays

Host resistance models

Conclusion

References

Chapter 7 Nonclinical evaluation of the potential for hypersensitivity

Introduction

Prediction of immune-mediated hypersensitivity

Pseudoallergy

Conclusion

References

Chapter 8 Nonclinical evaluation of the potential for autoimmunity

Introduction

Systemic autoimmune reactions

Organ-specific autoimmune reactions

Conclusion

References

Chapter 9 Regulatory aspects of immunotoxicity evaluation

Introduction

Early immunotoxicity regulations

Recent immunotoxicity guidelines

Conclusion

References

Chapter 10 Nonclinical strategies of immunotoxicity evaluation and risk assessment

Introduction

Good laboratory practices in immunotoxicology

Strategies for the prediction of immunosuppression

Strategies for the prediction of immunostimulation

Strategies for the prediction of hypersensitivity

Strategies for the prediction of autoimmune reactions

Risk assessment

Conclusion

References

Chapter 11 Clinical immunotoxicology

Introduction

Objectives of clinical immunotoxicology

Clinical assessment of immunotoxicity

Biomarkers of immunotoxicity

Environmental epidemiology studies

Disease clusters and sentinel diseases

Conclusion

References

Chapter 12 Immunotherapy of human poisonings

Introduction

Experimental studies

Clinical studies

Mechanism of specific antibodies efficacy

Conclusion

References

Chapter 13 Chemical immunoteratology and developmental immunotoxicology

Introduction

Immunity in newborns

Chemical teratogens and the immune system

Developmental immunotoxicants

Conclusion

References

Chapter 14 Immunotoxicity a