Pharmaceutical Manufacturing Encyclopedia
Elsevier, 22 окт. 2013 г. - Всего страниц: 3846
This industry standard encyclopedia on pharmaceutical manufacturing processes has been completely updated to include FDA drugs approved up to the summer of 2004. The encyclopedia gives details for the manufacture of 2226 pharmaceuticals that are being marketed as a trade-named product somewhere in the world. Each entry includes:
ò Therapeutic function
ò Chemical and common name
ò Structural Formula
ò Chemical Abstracts Registry no.
ò Trade name, manufacturer, country, and year introduced
ò Raw Materials
ò Manufacturing Process
In addition, references are also cited under each drug's entry to major pharmaceutical works where additional information can be obtained on synthesis and the pharmacology of the individual products.
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acetic acid acetone added addition alcohol allowed anhydrous aqueous Assigned base bath benzene boiling bromide carbonate Chemical Abstracts Registry Chemical Name chloride chloroform chromatography collected column combined Common Name concentrated containing cooled Country Year Introduced crude crystals diluted dissolved distilled dried dryness ester ethanol ether ethyl acetate evaporated extracted filtered filtrate followed France Germany give grams heated hydrochloric acid hydrochloride Italy Japan Kleeman and Engel layer Manufacturing Process melting point minutes mixture was stirred ml of water mmol mole Name Manufacturer Country obtained organic Patent Pharm phase potassium precipitate prepared Raw Materials reaction mixture recrystallized reduced pressure References Merck Index reflux removed residue resulting room temperature salt separated sodium bicarbonate sodium hydroxide solid solution solvent Spain stirred Structural Formula suspension Therapeutic Function Trade Name Manufacturer treated vacuo vacuum washed washed with water yield