Molecular Genetics of Sex Determination

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Stephen S. Wachtel
Academic Press, 23 июл. 2014 г. - Всего страниц: 518

In this era of accelerated discovery and prolific output, Molecular Genetics of Sex Determination keeps readers abreast of this fields fast-moving biology. Its chapters were completed by experts in eacharea only months before publication. The text is organized into two parts. First, it reviews the basic biology of sex determination and summarizes ground-breaking work in mouse, marsupial, and Drosophila systems. Second, it covers current human genetics, clinical studies, and the syndromes of abnormal sex differentiation.

With chapters by preeminent reproductive biologists, this is a capital work. Ohno's law is described by Ohno; the Lyon hypothesis, by Lyon; Sinclair tells how he cloned the testis-determining gene; and so on. Molecular Genetics of Sex Determination is authoritative, comprehensive, and current. It is prime reading for geneticists, developmental biologists, graduate students in these and related fields, clinical researchers, physicians, and medical students.

  • Reviews the genetics of sex determination in 19 up-to-date chapters
  • Features research on sex chromosomes and sex-determining genes
  • Includes abnormalities of sex determination and clinical genetics
  • Written by scientists who pioneered work in this field
 

Избранные страницы

Содержание

Chapter 1 The Search for the MaleDetermining Gene
1
Chapter 2 The Cloning of SRY
23
Chapter 3 The Mouse Y Chromosome
43
Chapter 4 XX Sex Reversal in the Mouse
69
Chapter 5 XY Sex Reversal in the Mouse
83
Chapter 6 Conservation of the XLinkage Group in Toto by All Eutherian Mammals
107
Chapter 7 XChromosome Inactivatïon
123
Chapter 8 Sex Determination in Marsupialsand Monotremes
143
Chapter 12 XX Sex Reversal in the Human
267
Chapter 13 XY Sex Reversal in the Human
287
Chapter 14 Phenotypic Correlations of XChromosome Loss
311
Chapter 15 Molecular Genetics of Androgen Insensitivity Syndromes in Humans
341
Chapter 16 Male Pseudohermaphroditism
367
Chapter 17 Molecular Genetics of Steroid 21Hydroxylase Deficiency
399
Chapter 18 The Gene for AntiMüllerian Hormone
439
Critical Roles in Sexual Differentiation
457

The Initiation of Sex Determination in Drosophila
171
Chapter 10 The Human Y Chromosome
205
Chapter 11 DNA Sequence Homology between the Human Sex Chromosomes
225
Index
503
Авторские права

Другие издания - Просмотреть все

Molecular Genetics of Sex Determination
Stephen S. Wachtel
Просмотр фрагмента - 1994

Часто встречающиеся слова и выражения

21-hydroxylase abnormalities activity adrenal allele amino acid analysis androgen receptor autosomal binding Biol Cell Cambridge Clin cloned confirmed conserved deficiency defined deletion map detected differentiation DNA-binding Donahoe Drosophila duct embryos encodes Endocrinol enzyme eutherian exon expression female-specific Ferguson-Smith fetal findings first fragment function Genet genitalia genome germ cells gonadal dysgenesis Goodfellow H-Y antigen homologous hormone human Y chromosome hybridization identified inactivation karyotype Koopman locus Lovell-Badge male pseudohermaphroditism mammalian mammals marsupial meiosis mice Miillerian molecular mouse Y chromosome mRNA mutations Nature London normal opsin ovarian ovary ovotestes patients phenotype probes protein pseudoautosomal region pseudogene recombination Sertoli cells sex chromosomes sex determination sex reversal short arm Sinclair somatic species specific spermatogenesis splicing steroid studies SXL protein testicular testis testis-determining gene tissue transcription transgenic translocation Turner syndrome Wachtel X-chromosome X-inactivation XX males XY females XYd sex reversal Y chromosome Y-specific

Библиографические данные

НазваниеMolecular Genetics of Sex Determination
РедакторStephen S. Wachtel
ИздательAcademic Press, 2014
ISBN1483295583, 9781483295589
Количество страницВсего страниц: 518
  
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