The Clinical Pharmacology of Biotechnology Products: Proceedings of the Esteve Foundation Symposium IV, Son Vida, Mallorca, 7-10 October 1990Excerpta Medica, 1991 - Всего страниц: 331 Researchers in new biology, clinical pharmacologists, physicians, and administrators have bundled their knowledge to produce this enlightening book, covering a broad range of subjects, contributing to helping new biology, through biotechnology, achieve its potential of improving the health of all people everywhere. First, the book takes a general look at biotechnology as a source of drugs. Next is discussed the disposition and pharmacokinetics of peptides and proteins since these differ from the disposition and kinetics of small organic molecules, the traditional types of drugs. Assessing the safety of biotechnology products, and the safety assessment of small organic molecules is also a topic covered by the book, as well as an overview of some of the ways the products of the new biology will have an impact, financially and otherwise, on society. |
Содержание
Converting a culture broth into a medicine | 3 |
Discussion | 21 |
Discussion | 35 |
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1991 Elsevier Science administration affinity amino acid anemia animal antagonists antigen approved assays B.V. Biomedical Division binding biological biotechnology drugs biotechnology products Blood bone marrow catabolism cell lines chromatography chronic Clin clinical pharmacology clinical trials compounds concentrations contamination conventional drugs cortisol cost cytokines detection Diabetes disease dosage dose drug development effects erythropoietin evaluation FGF receptors fibrin gamma glycosylation GM-CSF growth factors growth hormone hematopoietic heparin Hepatitis hirudin hospital hybridoma IFNy imipenem immunogenicity increase indications inhibitor injection insulin Interferon interleukin intravenous leuprolide levels M.M. Reidenberg marketing mg/kg molecular weight molecule monoclonal antibodies myocardial infarction neutropenia neutrophil normal patients peptides pharmaceutical pharmacokinetics pharmacology pharmacology of biotechnology phase plasma potential preclinical protein drugs Publishers B.V. Biomedical purification rDNA recombinant DNA recombinant proteins regulatory renal response Science Publishers B.V. serum specific stimulate streptokinase subcutaneous t-PA techniques testing therapeutic therapy toxicology transdermal treatment urine