Advanced Organic Chemistry of Nucleic Acids
Z. Shabarova, A. Bogdanov Advanced Organic Chemistry of Nucleic Acids Sequencing, cloning, transcription -- these are but a few key techniques behind the current breathtaking advances in molecular biology and biochemistry. As these methods continuosly diversify, biochemists need a sound chemical understanding to keep the pace. Chemists beginning working in the molecular biology lab need an introduction to this field from their point of view. This book serves both: it describes most of the known chemical reactions of nucleosides, nucleotides, and nucleic acids in sufficient detail to provide the desired background, and additionally, the fundamental relations between sequence, structure and functionality of nucleic acids are presented. The first edition of this book, which was published in Russian, has immediately become a recognized standard reference. This second, thoroughly revised and updated edition, now published in English, is likely to achieve a similar position in the international scientific community.
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5'-phosphate active acyl adenine adenosine agents alkaline alkyl already amino analysis anhydrides atom attack base becomes bond chemical cleavage cleaved complex compounds containing corresponding cyclic cytosine derivatives determined easily effect enzymatic enzyme example formation four fragments function gene gives guanine heterocyclic bases HOCH hydrolysis hydroxyl hydroxyl group interactions internucleotide linkage involving isolated known labeled latter mechanism medium method mixture modification moiety molecular molecule monomer namely nature nitrogen nucleic acids nucleophilic nucleotide sequence nucleotides obtained OH OH oligonucleotides pairs pentose phosphate group phosphorus atom polymer polynucleotide position possible presence primary structure primer procedure proceeds properties purine pyrimidine reaction removal residue respect restriction result ribonucleoside ring RNase separation sequencing shown similar solution specific stable step strands structure studies substitution synthesis Table terminal tion tRNA units usually weight yield он