Cancer Virus: The discovery of the Epstein-Barr Virus
OUP Oxford, 27 февр. 2014 г. - Всего страниц: 256
The Epstein-Barr virus (EBV) was discovered in 1964. At the time, the very idea of a virus underlying a cancer was revolutionary. Cancer is, after all, not catching. Even now, the idea of a virus causing cancer surprises many people. But Epstein-Barr, named after its discoverers, Sir Anthony Epstein and Dr Yvonne Barr, is fascinating for other reasons too. Almost everyone carries it, yet it is only under certain circumstances that it produces disease. It has been associated with different, apparently unrelated, diseases in different populations: Burkitt's Lymphoma, producing tumours in the jaw, in African children; a nasal tumour in China; glandular fever in Europe and the USA; and the majority of cases of Hodgkin's Disease everywhere. This book tells the story of the discovery of the virus, and the recognition of its connection with these various diseases - an account that spans the world and involves some remarkable characters and individual stories.
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The Eureka Moment
An accident of nature an accident
Hodgkin Lymphoma and the TNK cell
Making Sense of a Human Cancer Virus
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Africa animals Anthony Epstein antibody antibody levels antigen biopsy blood bone marrow Burkitt Lymphoma cells cancer virus capsid cause cell type cellular cent chapter chemotherapy chromosomal translocations chromosome clinical colleagues culture Denis Burkitt detected Diehl discovery disease donor early EBNAs EBV EBV antibody EBV DNA EBV research EBV’s EBVassociated EBVpositive epithelial cells EpsteinBarr virus genes genetic genome growth Hausen Henles herpesvirus Hodgkin Lymphoma Hospital human tumour immune response immune system immunoglobulin infected cells infectious mononucleosis involved Kampala killer T cells Klein Kuluva laboratory Lancet leukaemia longterm lymphocytes Lymphoma cell lines malaria malignant Mulago Hospital nasopharyngeal carcinoma NK cells normal NPC incidence oncogene population posttransplant lymphoma present primary EBV infection proteins rare ReedSternberg cells reports samples scientists seen sequence serum showed specific transforming translocation treatment tumour cells Uganda vaccine viral virus genome virus infection virus particles viruses