A History of Genetics

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CSHL Press, 2001 - Всего страниц: 174
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In the small “Fly Room†at Columbia University, T.H. Morgan and his students, A.H. Sturtevant, C.B. Bridges, and H.J. Muller, carried out the work that laid the foundations of modern, chromosomal genetics. The excitement of those times, when the whole field of genetics was being created, is captured in this book, written in 1965 by one of those present at the beginning. His account is one of the few authoritative, analytic works on the early history of genetics. This attractive reprint is accompanied by a website, http://www.esp.org/books/sturt/history/ offering full-text versions of the key papers discussed in the book, including the world's first genetic map.

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The text itself is very informative and interesting. Sturtevant account is, however, quite biased if we take into account other sources. The population and evolution bits were quite outdate at the time of publication. it is worth reading it, though. Читать весь отзыв


Before Mendel
to 1900
The Rediscovery
Genes and Chromosomes
The Fly Room
Development of Drosophila Work
Genetics of Continuous Variation
Sex Determination
Position Effect
Genetics and Immunology
Biochemical Genetics
Population Genetics and Evolution
The Genetics of Man
General Remarks

Cytological Maps and the Cytology of Crossing Over

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Стр. 12 - Those who survey the work done in this department will arrive at the conviction that among all the numerous experiments made, not one has been carried out to such an extent and in such a way as to make it possible to determine the number of different forms under which the offspring of hybrids appear, or to arrange these forms with certainty according to their separate generations, or definitely to ascertain their statistical relations*.
Стр. 49 - The supposition that particles of chromatin, indistinguishable from each other and indeed almost homogeneous under any known test, can by their material nature confer all the properties of life surpasses the range of even the most convinced materialism.
Стр. 122 - We are vertebrates because our mothers were vertebrates and produced eggs of the vertebrate pattern; but the color of our skin and hair and eyes, our sex, stature, and mental peculiarities were determined by the sperm as well as by the egg from which we came.
Стр. 21 - we may easily suppose circumstances in which such and such a variation if it occurred might be beneficial," and the like. The whole argument is based on such assumptions as these — assumptions which, were they found in the arguments of Paley or of Butler, we could not too scornfully ridicule. " If," say we with much circumlocution, " the course of Nature followed the lines we have suggested, then, in short, it did.
Стр. 37 - I may finally call attention to the probability that the association of paternal and maternal chromosomes in pairs and their subsequent separation during the reducing division as indicated above may constitute the physical basis of the Mendelian law of heredity.
Стр. 129 - They would have been strictly accurate had the clause 'at birth' been inserted after the word equal. It is what happens to individuals after birth that makes one a hewer of wood and a drawer of water, another a diplomat, a thief, a successful business man or a far-famed scientist. What our advocates of freedom in 1776 took no account of is the fact that the...
Стр. 10 - EXPERIENCE of artificial fertilisation, such as is effected with ornamental plants in order to obtain new variations in colour, has led to the experiments which will here be discussed.
Стр. 47 - Morgan about this attempt — -which we agreed had nothing in its favor — -I suddenly realized that the variations in strength of linkage, already attributed by Morgan to differences in the spatial separation of the genes, offered the possibility of determining sequences in the linear dimension of a chromosome. I went home, and spent most of the night (to the neglect of my undergraduate homework) in producing the first chromosome map, including the sex-linked genes y, w, v, m, and r, in the order,...
Стр. 7 - In the opinion of renowned physiologists, for the purpose of propagation one pollen cell and one egg cell unite in Phanerogams' into a single cell, which is capable by assimilation and formation of new cells to become an independent organism. This development follows a constant law, which is founded on the material composition and arrangement of the elements which meet in the cell in a vivifying union.
Стр. 129 - ... diversity of their experience of life. How few of these could have changed parts with each other. Many of these types are, even in present conditions, almost differentiated into distinct strains. In no wild species, not even among the ants, so often quoted, do we find any polymorphism approaching to this. I never cease to marvel that the more divergent castes of civilized humanity are capable of interbreeding and of producing fertile offspring from their crosses. Nothing but this paradoxical...

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